人类暴力攻击行为的遗传相关性研究进展

人类暴力攻击行为是受遗传因素与环境因素共同影响而导致的复杂行为,从遗传学角度探究暴力攻击行为的机制已成趋势。本文对几个与暴力攻击行为相关的候选基因以及一些暴力攻击行为在表观遗传学上的研究进展进行综述,并探讨了从基因多态性和表观遗传学角度探究暴力攻击行为的前景与意义。     

精神分裂症患者书写特征与治疗效果相关性

目的研究精神分裂症患者书写特征与治疗效果的相关性,探讨具有攻击行为对患者书写特征的影响。方法收集精神分裂症患者在入院时,治疗1周、2周、4周、8周的随意书写和固定摘抄,并进行阳性和阴性症状量表(Positive and Negative Syndrome Scale,PANSS)及修订版外显攻击行为量表(Modified Overt Aggression Scale,MOAS)评分。选取"字体与格线关系"、"有无大笔画"两项书写特征进行治疗前后比较。结果精神分裂症患者治疗8周后PANSS得分下降,病情好转,书写特征有改善;有攻击行为的患者书写特征在治疗前后差异有统计学意义(P0.05)。结论精神分裂症患者的书写特征变化与治疗效果具有相关性,有攻击行为的精神分裂症患者书写特征异常变化在治疗后有改善。     

ω-3多不饱和脂肪酸与暴力攻击行为间关系的研究进展

20世纪80年代起,ω-3多不饱和脂肪酸与暴力攻击行为间的关系逐渐引起人们的关注。随后,大量的流行病学调查发现ω-3多不饱和脂肪酸和暴力攻击行为间具有一定的相关性,在不同人群中进行的干预实验也证实ω-3多不饱和脂肪酸能在一定程度上预防或减轻暴力攻击行为。本文综述了ω-3多不饱和脂肪酸和暴力攻击行为的相关性,并简单介绍了这些研究中可能存在的影响因素及ω-3多不饱和脂肪酸影响暴力攻击行为的可能机制。     

精神分裂症患者攻击行为相关因素的研究进展

<正> 精神病人的攻击行为给自己及社会造成危害,并常涉及法律问题。大多数研究认为,精神病人攻击行为的发生率高于精神正常人群。在有攻击行为的重型精神病患者中,主要是精神分裂症患者。许多研究者     

云南汉族NR3C1基因多态性与暴力攻击行为相关性

目的为了探讨云南汉族人群糖皮质激素受体基因(NR3C1)多态性与攻击行为的相关性。方法应用改良多重高温连接酶反应(improve multiplex ligasedetection reaction,iMLDR)技术检测194例云南汉族有攻击行为的监狱服刑人员和301例健康对照样本的NR3C1基因SNPs(rs6190、rs6191、rs6198、rs41423247、rs56149945)基因型,采用SPSS19.0软件、PHASE2.1平台进行统计学分析。结果 rs6191和rs41423247单个基因座的等位基因分布在非攻击组与攻击组、抢劫亚组和故意伤害亚组中均无显著性差异;rs41423247的基因型在非攻击组与抢劫亚组中的分布有显著性差异(p=0.048);构建的4种单倍型分布在非攻击组与攻击组、抢劫亚组和故意伤害亚组中均无显著性差异。结论云南汉族人群NR3C1基因的rs41423247基因座的单基因座多态性可能与指向他人的躯体攻击行为相关,rs6191基因座的单基因座多态性可能与暴力攻击行为无关。     

云南汉族CRHBP基因多态性与暴力攻击行为的相关性

目的探讨云南汉族人群促肾上腺皮质激素释放激素结合蛋白(corticotropin releasing hormone-binding protein, CRHBP)基因多态性与暴力攻击行为的相关性。方法对云南汉族111例有攻击行为的服刑人员(包含53例抢劫,58例故意伤害)和189例健康对照样本采用改良的多重高温连接酶检测反应技术(improve Multiplex ligase detection reaction, iMLDR)检测CRHBP基因的4个Tag SNPs(rs10062367, rs32897, rs7718461, rs7721799)的基因型,应用SPSS 20.0和SHEsis软件对结果进行统计分析。结果 rs32897、rs7718461、rs7721799的等位基因和基因型分布在暴力组、抢劫亚组、故意伤害亚组和对照组中均无显著差异(P>0.05),rs10062367等位基因和基因型分布在暴力组、抢劫亚组和对照组中也无显著差异(P>0.05),但在故意伤害亚组与对照组中具有显著差异(P<0.05)。单倍型ATGA可使暴力的相对风险显著增高(P<0.05),单倍型GCAA可使指向他人暴力的相对风险显著增高(P<0.05)。结论 CRHBP基因rs10062367位点多态性可能与云南汉族人群针对他人的攻击行为有关,单倍型ATGA是暴力行为的风险因子,个体携带单倍型GCAA会使指向他人的躯体攻击行为风险增加。     

青少年暴力攻击行为影响因素探讨

青少年时期是生理心理发育的关键时期,也是心理冲突和情绪、行为问题的高发阶段,暴力攻击行为便是其中较为突出的问题之一。本文分别从认知心理学、社会心理学、生理遗传学、人格心理学、环境等视角探讨了影响青少年暴力攻击行为发生的因素。在此基础上,得出青少年暴力攻击行为是由几种影响因素综合作用而产生的。     

MOAS在住院精神障碍患者暴力风险评估中的应用

目的探索修订版外显攻击行为量表(Modified Overt Aggression Scale,MOAS)用于预测精神障碍住院患者发生严重攻击行为的价值,为住院精神障碍患者的暴力风险评估提供理论依据。方法由经过培训的医务人员对某精神卫生专科机构2009年9月在院的918例住院患者采用MOAS进行评估,并随访2年内是否发生严重攻击行为。通过SPSS 21.0分析采用MOAS评估预测精神障碍患者发生严重攻击行为的价值。结果 (1)与未发生严重攻击行为者相比,2年内发生严重攻击行为者,其MOAS评分中言语攻击、财物攻击、身体攻击和加权总分存在差异(P0.05);(2)MOAS中的言语攻击评分,与2年内精神障碍患者的严重攻击行为相关(P0.05);(3)通过MOAS各项评分预测2年内精神障碍患者是否出现严重攻击行为时,言语攻击、体力攻击及加权总分三项评分存在一定的价值(P0.05)。结论 MOAS评分用于预测住院的精神障碍患者2年内发生的严重攻击行为时,存在一定的价值。     

遗传基因多态性与精神分裂症患者暴力行为关系的研究进展

精神分裂症是一种以思维障碍为主要表现,同时伴有感知、情感和行为方面障碍的常见疾病。患者可以在精神症状的支配下,出现自伤或冲动伤人行为,造成公共危害,增加家庭和社会负担。近年来陆续有研究表明精神分裂症患者的暴力行为与遗传因素相关联。本文综述了遗传基因多态性与精神分裂症患者暴力行为关系的研究进展,分析了两者间形成关联的可能机制,提出了目前研究存在的局限性以及未来的研究方向,为精神分裂症患者暴力行为的风险评估和预防控制提供科学依据。     

38例精神分裂症患者凶杀行为研究

目的　探讨精神分裂症患者的凶杀犯罪行为各个方面的特点。　方法　对 38例具有凶杀行为的精神分裂症患者 ,在心理学、生理学、社会学等各方面进行实例分析。　结果　这些患者在犯罪动机、行为特点、犯罪工具、被害人等诸多方面与正常人的凶杀犯罪有明显的差异。　结论　应加强对精神分裂症患者的诊治 ,普及精神卫生的知识 ,从而预防、控制犯罪。     

Alternative Pathways to Violence in Persons with Schizophrenia: The Role of Childhood Antisocial Behavior Problems

Violence in schizophrenia patients may result from many factors besides the symptoms of schizophrenia. This study examined the relationship between childhood antisocial behavior and adult violence using data from the NIMH CATIE study. The prevalence of violence was higher among patients with a history of childhood conduct problems than among those without this history (28.2% vs. 14.6%; P < 0.001). In the conduct-problems group, violence was associated with current substance use at levels below diagnostic criteria. Positive psychotic symptoms were linked to violence only in the group without conduct problems. Findings suggest that violence among adults with schizophrenia may follow at least two distinct pathways-one associated with premorbid conditions, including antisocial conduct, and another associated with the acute psychopathology of schizophrenia.     

BOLD—fMRI在肇事肇祸精神分裂症研究中综述

综述了肇事肇祸精神病患者脑功能异常区以及异常区之间的相互关系。主要采用事件相关的图片线索诱导一中性线索反应模式的fMRI扫描，对司法鉴定为精神病患者进行的探索实验性研究。结果表明，双侧大脑额叶、颞叶区域存在多个脑功能激活区。因此，脑功能成像（fMRI）可以作为肇事肇祸精神病司法鉴定的一个有效手段。     

The relation of ADHD and violent aggression: What can we learn from epidemiological and genetic studies?

Disruptive behavior includes psychopathological and behavioral constructs like aggression, impulsivity, violence, antisociality and psychopathy and is often closely related with diagnostic categories like conduct disorder (CD), attention deficit disorder (ADHD) and antisocial personality disorder (ASP). There is now clear evidence that neurobiological and environmental factors contribute to these phenotypes. A mounting body of evidence also suggests interactive effects of genetic and environmental risks.In this selective review we give an overview over epidemiological aspects of the relation between ADHD and antisocial behavior, including violent aggression and psychopathy. Moreover, we summarize recent findings from molecular genetic studies and particularly discuss pleiotropic effects of a functional polymorphism of the serotonin transporter promoter gene (5HTTLPR) and childhood adversity on ADHD and violent behavior. The reported gene–environment interactions are not only informative for understanding the neurobiological underpinnings of disruptive behavior, but also throw some light on the relation between ADHD and violent behavior from a genetic perspective. The impact of genetic research on forensic psychiatry and future directions of neurobiological research are discussed.     

Characteristics of assaultive patients with schizophrenia versus personality disorder: six year analysis of the Assaulted Staff Action Program (ASAP)

Literature reviews of individual assaultive patients, repetitively violent patients, and restrained assaultive patients document that persons diagnosed with schizophrenia or personality disorder are at the highest risk to become assaultive. While there has been some initial research of possible predictor variables across diagnostic groups, this six-year retrospective study is the first to compare only persons with schizophrenia or personality disorder on basic demographic and the selected clinical variables of history of violence, personal victimization, and substance use disorder. In this study, the variance suggested that persons with schizophrenia and personality disorder were both likely to be assaultive. Assaults by persons with schizophrenia were somewhat proportional to their presence in the population studied. However, personality disordered patients represented a disproportional increase from the population studied. Younger females with a diagnosis of personality disorder and with histories of violence toward others and personal victimization appeared at increased risk to be assaultive and to require restraints. The findings and their implications for safety and clinical care are discussed.     

Study: The Lack of Significant Association of the Catechol-O-Methyl Transferase (COMT) Gene Polymorphism in Violent Offenders with Mental Retardation

Abstract:  Little is known about criminality of cognitively impaired people and also there have been no reports on the relationship between catechol- O -methyl transferase (COMT) and committed Mental Retardation (MR) subjects. In the present study, the association between committed (violent offences) MR subjects and genetic variants of COMT were investigated by using polymerase chain reaction and based restriction fragment length polymorphism methods. During 6 years of follow-up, 36 violent offenders with mild MR were investigated. Thirty-six control volunteers were included in the study as a control group. H/L polymorphism of the COMT gene was investigated in these two groups. In conclusion, the COMT gene genotype distribution and allele frequency is not significantly different between the two groups ( p  > 0.05). This result suggests that the H/L polymorphism of the COMT gene does not show an association with the potential of "commits-violent offense" of Turkish subjects with mental retardation, compared with control group.     

DRD3基因对精神分裂症研究的法医学意义

阐明精神分裂症的病因和发病机制是医学面临的重要挑战之一,同时也是法医司法鉴定的重要内容之一。精神分裂症的多巴胺假说认为多巴胺能系统的失调是精神分裂症的病因,DRD3基因在脑中的区域性高表达以及其与众多精神疾病的阳性关联提示其在精神分裂症中的潜在重要性。本文综述了DRD3基因在精神分裂症的群体遗传学、动物模型和在人源细胞表达情况的研究现状,认为DRD3基因参与精神分裂症的发病机制并且在未来可能作为一个重要的遗传学指标而应用到法医精神病学的鉴定当中。     

Violence ratings of female patients in broadmoor hospital

Abstract

A study is described which characterised the female population of Broadmoor Special Hospital on a scale (Robertson et al., 1987) which rates violence associated with the index offence and previous episodes of violence both in terms of prosecuted violence and unprosecuted incidents. This scale has been applied recently to the male population of Broadmoor (Wong et al., 1993). The findings here confirm the notion that the female population of a Special Hospital are less violent than the males in terms of rating of violence associated with the index offence and in previous convictions for violent offending. The females contain a larger proportion of patients convicted of the offence of Arson (index offence) and patients transferred from other hospitals because of being unmanageable in these settings (under Section 3 of the Mental Health Act). Extreme ratings of violence amongst the females is associated with a diagnosis of personality disorder rather than schizophrenia or psychosis.     

Effects of Family Violence on Child Behavior and Health During Early Childhood

Looking at families where children have been abused/neglected in early childhood, this study examined measures of child behavior and health to see if they tended to be worse when domestic violence is or has been present in a family. Further, caregiver and family characteristics as well as other case factors were examined, as possible moderators or mediators of the effects of domestic violence. Results indicate that domestic violence, of the type and severity occurring in our sample, does not have a direct effect on child outcomes by Age 6, when other associated variables are taken into account, but has considerable indirect effects. There is a pronounced impact of domestic violence on family functioning, the caregiver's general health and well being, and the quality of the caregiver's interaction with the child, which in turn are significantly associated with decrements of child functioning related to behavior problems and health. Some implications of this study for research in the area of domestic violence and child maltreatment are discussed.     

Examining the moderating role of family cohesion on the relationship between witnessed community violence and delinquency in a national sample of adolescents

Witnessed community violence has been linked to a number of internalizing and externalizing problems in adolescents. Guided by Cicchetti and Lynch's (1993) ecological-transactional model, this study aimed to examine the impact that family-level factors had on negative outcomes associated with witnessed community violence. Using a nationally representative sample, we explored the moderational role of family cohesion in the relationship between witnessing community violence and delinquent behavior while taking demographic variables into account. Results from the investigation suggested that low levels of family cohesion were predictive of delinquency after controlling for race, gender, past delinquency, and direct trauma. In addition, the findings suggested that family cohesion moderated the impact of witnessed community violence on future delinquent behavior. Future directions for research and implications for practice were also discussed.     

Criminality and moral dysfunctions: neurological,biochemical, and genetic dimensions

In this article, the author attempts to demonstrate a relationship between neurobiological dysfunctions and/or genetically determined deviant behavior and personality traits as well as moral abnormalities. Data from neuroscience show that a number of neurological dysfunctions are linked to cognitive and emotional disturbances. Cognitive and emotional abnormalities, in turn, are frequently related to moral dysfunctions. Moreover, neurological disorders can produce dramatic psychological and social problems, personality changes, and behavioral problems in patients. Those mental, emotional, and psychosocial problems and related moral dysfunctions are frequently linked to violence and/or criminal behavior. Genetic research found evidence of inheritability of antisocial traits, which interfere with moral development and activities. This information has consequences for any assessment and disposition within the legal system. More research on the interrelationship between neuro(bio)logical, genetic, emotional, and mental aspects of moral dysfunctions is needed for the development of adequate treatment, prevention, and intervention programs.