32例无心外原因猝死者传导系统病理学观察

在对32例无心外原因猝死者传导系统(CCS)组织学观察中,发现31例 CCS 有异常和病变,其中11例可致猝死。这些病变包括有急性炎症、出血、脂肪浸润和结内外神经病变,且与猝死有关。     

心脏传导系统的增龄性变化

心脏传导系统（CCS）包括窦房结（SAN）、房室结（AVN）、房室束（又称希氏束，HB）、左右束支（LBB，RBB）及其终末纤维网，其功能是把心脏搏动的冲动传导到整个心脏，以协调心脏的节律性收缩．近年来，CCS病变与猝死的关系引起重视，已有研究表明，一些猝死与CCS的病变有关。但在实际应用中，必须将CCS增龄变化同其病变区分开来，以免误将其正常增龄变化视为病变，导致错误的结论．1SAN的年龄变化在光镜水平，Lev[1]首先对53例4个月胎儿至90岁老人的SAN进行了分年龄组观察；Davies[2]对50岁以下和75岁以上两组各50例的SAN…     

心肌炎侵及心传导系统病理学观察

本研究采用已建立的人体心脏传导系统简易取材法,对6例心肌炎的案例进行了传导组织的病理学观察,结果发现6例心肌炎患者CCS均有明显炎症,尤以SAN、AVN病变为主;推测CCS炎症可能为心肌炎患者猝死的主要原因。因此,本文提出对怀疑心性猝死案例应作常规传导系统检查。     

120例心性猝死心传导系统观察分析

心传导系统（CCS）在心性淬死者中的病理学意义存有争论。有的学者认为有一定意义[1，2]，有的学者持否定态度[3，4]。争论的焦点在于：（1）CCS具有生理性变化，难以判定病变标准；（2）形态学上CCS虽检见病变，但无心电图资料，是否具有临床意义及诊断价值。过去的CCS检查法烦琐，难以作较大量的案例分析。为此，笔者收集了120例经系统尸体解剖检查、部分做了毒物分析，并排除心外原因的摔死者的心脏标本，常规检查CCS以探讨其在心性碎死者中的法医学鉴定的意义。材料与方法材料来自1989年1月至1995年12月期间，广州地区的尸检案例…     

10例死因不明者心脏传导系统观察

心脏传导系统(CCS)疾病可引起猝死已得到公认,但其各种病变的具体意义尚需更多的资料积累。本文观察了10例经过常规检查,未发现明确死因者的CCS,现将其CCS的病理学改变报道如下:1材料与方法2000年~2004年间沈阳市公安局受理的10例尸检,均经过系统的尸体解剖、病理组织学和毒物分析学检查,排除了暴力、中毒和常见疾病致死。按宋一璇、姚青松[1]介绍的方法检查CCS,常规脱水、石蜡包埋,连续切片,间断取片。每例取25~35片,HE染色,少数经Masson三色染色,光镜检查。表1一般资料及心脏常规检查结果编号性别年龄职业心重(g)冠脉狭窄心脏病变死…     

19例创伤性心传导系统出血的病理学观察

胸背部受力引起心脏破裂或心肌挫伤致死，已有不少文献报道。但伴有心传导系统（CCS）损伤出血，甚至由此发生死亡，尚未引起注意。作者观察了19例，现报道如下。材料与方法19例材料来自广州市刑科所尸检案例。尸体低温保存24～36h后解剖，全部心脏（部分案例全部器官）均经10％福尔马林固定后常规检查，CCS取材按文献方法［1］切取，HE染色，光镜下观察。结果三．性别与年龄男性16例，女性3例。年龄最小18岁，最大55岁。其中50岁以下者17例。2．致伤原因钝器打击15例，交通事故3例，坠落1例。3．伤后至死亡时间～30min7例，～Zh8例，～…     

心脏神经病

目的 研究心源性猝死的病理形态学。方法 用本组建立的CCS检查法对179例心源性猝死者作常规CCS组织学检查。结果 发现8例心脏神经或神经节内有出血、炎症或肿瘤浸润,伴神经组织水肿、变性、坏死,而其他病变不足以解释猝死。结论 一切原发或继发性心脏神经病均可致猝死。     

心肌及传导组织内3种蛋白的变化与SMDS的相关性

目的 观察心肌及传导组织内肌动蛋白、血浆白蛋白及纤维连接蛋白的染色变化，探讨青壮年猝死综合征(SMDS)死后诊断的新方法。方法 应用免疫组化S-P法，对SMDS及冠心病猝死者心肌及传导系统内肌动蛋白、血浆白蛋白和纤维连接蛋白的进行染色观察。结果 22例SMDS例猝死者心肌及传导系统内的肌动蛋白缺染17例；血浆白蛋白染色阳性18例；纤维连接蛋白染色阳性15例。并发现在SMDS中，8例有CCS严重病变。结论 心肌及传导系统内血浆蛋白、肌动蛋白改变与SMDS密切相关，部分SMDS病例死前存在早期心肌缺血或梗死的改变。     

车祸猛于虎 如何破解交通安全难题

根据全球各交通和警察部门的统计，2004年全世界交通事故死亡人数为50万人。其中，中国交通事故死亡人数为10．4万人，印度、美国、俄罗斯紧随其后．分别为8．6万人、4万人和2．6万人。中国的道路交通事故死亡人数在全国总死亡人数中排在脑血管、呼吸系统、恶性肿瘤．心脏病，损伤与中毒以及消化系统疾病后面，居第七位。而全世界的道路交通事故死亡人数在总死亡人数中层第十位，到上世纪末，世界道路交通事故从总体上来说或趋于下降，或趋千稳定。     

156例道路交通事故临床法医学鉴定分析

随着现代交通事业的发展，交通事故日趋增多。过去虽有一些交通事故死亡案例报道[1－6]，但其活体损伤的临床法医学研究未见报道。作者就本校法医门诊1991年受理的武汉地区156例道路交通事故活体损伤鉴定材料进行分析。损伤程度按司发［1990］6号和70号文件《人体轻伤鉴定标准（试行）》和《人体重伤鉴定标准》分为轻伤和重伤；伤残程度按GA35－92《道路交通事故受伤人员伤残评定标准》分为10级。案例资料分析1．发生率156例占同期775树活体鉴定的20％，而1990年的806例鉴定中仅门例（75％）；1991年比1990年增长1．7倍。2．受伤者的性别、…     

深圳市道路交通事故死亡案例特点分析

目的探讨道路交通事故死亡案例特点,为预防事故的发生提供可靠信息和参考数据。方法按照死者性别、年龄、死亡原因、事故发生时间及地点、事故车辆类型等相关参数,对深圳市4184例道路交通事故死亡案例进行回顾性分析。结果事故死亡人员以男性为主,男女比例为2.45∶1;事故在6：00～8：00和18：00～2：00发生最多;72%的案例在城郊主干道发生;死者主要交通行为方式分别为步行占44%,自行车骑车人19%,摩托车驾车人15%;肇事车辆以货车为主;死亡原因83.2%为颅脑损伤死亡,13.3%为多发损伤。结论深圳地区道路交通事故死亡案件具有明显特点,具有可防范性。     

Sudden death resulting from lesions of the cardiac conduction system

Sudden unexpected deaths in young persons with noncontributory histories, autopsy results, and drug screen results are a common problem in forensic pathology. As part of the evaluation of such cases, the cardiac conduction system (CCS) should be studied. To determine the type and incidence of lethal CCS lesions, the authors reviewed their files of sudden unexpected cardiac deaths with particular attention to cases with causes of death in the conduction system. Cases of sudden cardiac death in patients aged < or=40 years during a 10-year period (Michigan) and a 4 year-period (Spain) were selected from the files. From this group, cases were identified in which the cause of death was a lethal change in the CCS. The portions of the heart containing the CCS were excised, and at least one hematoxylin and eosin slide and at least one trichrome or elastic trichrome slide per block were studied. In the two centers, 381 cases of sudden cardiac death were identified. The most common causes of sudden cardiac death were arteriosclerotic narrowing of the coronary arteries, cardiomyopathy, and myocarditis. In 82 cases, there was no identifiable cause of death even after complete gross and microscopic autopsy was performed, a medical history was obtained, and a drug screen was performed. In 11 cases, the CCS contained lesions that were considered lethal: narrowing of the atrioventricular node artery by fibromuscular hyperplasia (7 cases) and atrioventricular node tumors (4 cases). The 11 cases accounted for 2.9% of the 381 cases of sudden cardiac death and 11.8% of the indeterminable cases. It was concluded that examination of the CCS in deaths in which the gross and microscopic autopsy, history, and drug screen fail to provide a cause of death can yield a cause of death in a significant percentage of cases. If heart block was not documented during life and no explanatory lesions were found during routine cardiac examination, examination of the CCS can yield valuable information.     

Prevalence of alcohol in blood samples from traffic accident cases in Turkey

Alcohol is one of the main causes of traffic accidents worldwide. With a population of 70 million, 12 million vehicles, and 18 million drivers (16% women), Turkey is one of the European countries that has a high incidence of road traffic accidents.In accordance with Turkish laws, subjects were considered to be positive when alcohol blood concentration exceeded 50 mg/100 mL. The objective of the present study was to obtain reliable and comparable data about alcohol use in traffic cases in Turkey. All cases are admitted to the emergency department at Ege University Medical Faculty. The cases from police officers are described as traffic control cases. Alcohol was detected in the blood of about 54.4% of the traffic-related cases during October 2005 to March 2007. It has been observed that, in 17.4% of the traffic accident cases, the blood alcohol level was 50 mg/dL or less, which is the legal limit in Turkey for car drivers. Alcohol prevalence was 57.2% in male cases and 43.6% in female cases. In alcohol-positive cases; the ratios for males were 1.73 times more frequent in traffic-related cases. Prevalence data will help traffic safety professionals to adequately allocate resources and plan future efforts in reducing drinking-and-driving behavior and thereby reduce traffic accidents.     

上海市城市轨道交通事故死亡案例分析

目的分析城市轨道交通事故死亡案例特点,为今后此类事故的法医学鉴定以及预防提供参考。方法收集上海市2005--2008年间城市轨道交通事故死亡案例18例,从案件的性质、损伤机制及特征等方面,总结此类案件的法医学特点。结果18例城市轨道交通事故死者,年龄在21～55岁。其中,自杀14例,意外4例;颅脑损伤死亡14例,创伤性休克死亡4例。损伤以撞击、摔跌伤为主,部分存在碾压伤。结论城市轨道交通事故所致损伤具有其特征性,案件性质主要为自杀,部分为偶然的意外事件,具有可防范性。     

道路交通事故颅脑损伤的法医学鉴定

目的　研究道路交通事故中颅脑损伤的类型、特点、主要并发症及其受伤人员的伤残评定。方法　 862例道路交通事故颅脑损伤的案例资料 ,按伤者受伤的不同部位、有无并发症、并发症的类型及伤残程度进行统计分析。结果　复合性颅脑损伤 2 76例 ,脑挫伤 192例 ,颅骨骨折 79例 ,颅内出血 91例 ,头皮外伤 2 2 4例 ;主要并发症为脑积水 ( 19例 ,2 2 0 % )、癫痫 ( 16例 ,1 86% )、偏瘫 ( 14例 ,1 62 % )、植物人状态 ( 12例 ,1 3 9% )。结论　道路交通事故中颅脑损伤 ,以头部复合性损伤最多见 ,严重的脑挫伤为最常见的损伤类型 ,并发症的诊断应掌握诊断标准 ,并注意与相关疾病鉴别。     

涉嫌酒后驾驶交通事故人体损伤与驾驶员血中乙醇质量浓度关系研究

目的探讨涉嫌酒后驾驶所致道路交通事故中人体损伤情况与驾驶员血中乙醇质量浓度关系,为预防、控制道路交通事故及人体损伤提供依据。方法对467例涉嫌酒后驾驶机动车的道路交通事故损伤人员相关鉴定资料与肇事驾驶员血中乙醇质量浓度进行系统分析性研究。结果涉嫌酒后驾驶发生道路交通事故的损伤人员中,以20~39岁男性居多;事故中驾驶员损伤机率最高;酒后交通事故以长头小车及摩托车最多,而驾驶员血中乙醇质量浓度（BAC）为0.1~20mg/100mL浓度的摩托车驾乘人员伤亡构成比最高;酒后驾驶机动车肇事导致的人体致命性损伤及人员死亡的饮酒组危险程度均高于未饮酒组,在驾驶员血中乙醇质量浓度（BAC）为0.1~20mg/100mL组与20.1~80mg/100mL组比较无明显差异。结论酒后驾驶肇事导致的人员伤亡比未饮酒驾车交通事故严重;未达酒后驾车组（BAC为0.1~20mg/100mL）和酒后驾车组（BAC为20.1~80mg/100mL）交通事故导致的人员伤亡无明显差异。研究结果提示,应降低饮酒后驾车血中乙醇质量浓度（BAC）法定标准阈值,进一步控制和减少道路交通事故人身伤亡率。     

Myocardial lesions induced after trauma and treatment.

In order to clarify the effect of trauma and treatment as stresses on myocardia, we examined histological changes of myocardia in victims who received various kinds of traumata and treatments. We also undertook a histochemical study for calmodulin, which we found useful in the diagnosis of early ischemia. Those who died shortly after stab wounds, traffic accident or head injuries, showed mild cardiac lesions such as contraction bands or fragmentation and mild diffusion of calmodulin, a marker for necrosis. A case with hemorrhagic shock after a traffic accident, involving intense resuscitation for 2 h, showed severe cardiac lesions such as contraction bands, hydropic change and subendocardial hemorrhage along with severe diffusion of calmodulin. In most of the instant death cases after falls, severe contraction band necrosis and severe calmodulin diffusion were observed. Myocardia of victims, who died several days after head injuries or traffic accidents, generally demonstrated distinct diffusion of calmodulin as compared to the mild and non-specific lesions detected by hematoxylin-eosin (H&E) staining. In cases of long-term survival in a state of brain death, calmodulin staining was very low, which was not always associated with the severity of the lesions on H&E staining. In cases with intensive or extended treatment, it appeared to be difficult to determine the cause-effect relationship between trauma and cardiac lesions or to distinguish the lesions due to extrinsic factors from those of disease. In some cases, calmodulin intensely stained the areas with hydropic appearance or hypereosinophilia, which may be related to calcium overload.     

Diffuse vascular injury in fatal road traffic accident victims: its relationship to diffuse axonal injury

The authors have reported a macro- and microscopic study of brain lesions in 120 victims of fatal road traffic accidents, independent of the survival time. Diffuse vascular injury (DVI) was found in 14 patients (11.7%). All patients with DVI died within 24 h after the accident. The 14 patients with DVI also showed severe (Grade 2 or 3) diffuse axonal injury (DAI). Since DVI is restricted to road traffic accidents and incompatible with life, the high frequency observed in our series could be explained by the fact that all 120 patients were victims of road traffic accidents, and 69.2% had died within 24 h after the accident. The association between DVI and severe DAI (Grades 2 and 3) suggests that both lesions depend on the same mechanism, with the degree of axonal and vascular damage being determined by the intensity of the head acceleration. Our results show a relationship between DVI and DAI that suggest there may be a spectrum or at least a continuum between these entities as distinct from DVI being a separate entity.     

交通意外事故尸体剖验37例

本文作者报告陆上交通意外尸体剖验37例。事故类型分路人车撞、汽车相撞、汽车撞静物及摩托车事故四种。路人被车撞致死者,损伤分布广,种类多,有5种不同的损伤。摩托车事故死亡者胸腹部损伤多,突出的是胸主动脉横裂。汽车驾驶员的损伤以胸腹部为多。其中因车撞车驾驶员死亡者,头部损伤常不严重。各种不同的损伤各有一定的特征。作者强调了要注意酒精与车祸的关系。