Sample Mining and Data Mining: Combined Real-Time and Retrospective Approaches for the Identification of Emerging Novel Psychoactive Substances

Novel psychoactive substances (NPS) are synthetic drugs that pose serious public health and safety concerns. A multitude of NPS have been identified in the United States, often implicated in forensic investigations. The most common and effective manner for identifying NPS is by use of mass spectrometry and the true utility lies within nontargeted acquisition techniques. During this study, a liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) assay was developed, validated, and implemented for forensic toxicology testing. A SCIEX TripleTOF™ 5600 + with SWATH^® acquisition was used. Resulting data were compared against an extensive library database containing more than 800 compounds. The LC-QTOF-MS assay was applied to the reanalysis of biological sample extracts to discover emergent NPS. More than 3,000 sample extracts were analyzed, and more than 20 emerging NPS were detected for the first time. Among these were isopropyl-U-47700, 3,4-methylenedioxy-U-47700, fluorofuranylfentanyl, N-methyl norfentanyl, 2F-deschloroketamine, 3,4-methylenedioxy-alpha-PHP, eutylone, and N-ethyl hexedrone.     

不同茯苓提取物对急性肝损伤小鼠的保护作用

目的 研究茯苓不同提取部位对四氯化碳（carbon tetrachloride，CCl4）所致急性肝损伤的保护作用，并探讨其可能的作用机制。方法 〖JP2〗将120只昆明小鼠随机分为正常组，模型组，阳性药物组（水飞蓟素100 mg/kg），茯苓水提物低、中、高剂量组（30、60、120 mg/kg），茯苓醇提物低、中、高剂量组（25、50、100 mg/kg）以及茯苓多糖低、中、高剂量组（10、20、40 mg/kg），连续灌胃两周后腹腔注射0.5% CCl4溶液诱发小鼠急性肝损伤。模型复制12 h后处死小鼠，检测血清中谷氨酸氨基转移酶（alanine aminotransferase，ALT）、天冬氨酸氨基转移酶（aspartate aminotransferase，AST）和肝组织中超氧化物歧化酶（superoxide dismutase，SOD）、丙二醛（malondialdehyde，MDA）及白细胞介素-1β（interleukin-1β，IL-1β）、白细胞介素-6（interleukin-6，IL-6）和肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）水平；苏木精-伊红染色观察肝组织病理切片。结果 各给药组肝组织病理损伤减轻。与模型组比较，各给药组小鼠ALT、AST、MDA、IL-1β、IL-6和TNF-α水平均显著降低（P<0.05），SOD活性显著升高（P<0.05），且茯苓多糖的作用呈剂量依赖性，以茯苓多糖高剂量组最接近阳性药物组。结论 3种茯苓提取物对CCl4诱导的小鼠肝损伤均具有不同程度的保护作用，以茯苓多糖效果最为显著，其机制可能与增强肝脏抗氧化能力及减轻炎症有关。     

大数据时代日本个人信息保护法探究

个人信息本来是极其隐私的事物,在大数据时代却时刻处于"裸奔"状态,时刻面临被侵犯的风险。特别在新冠肺炎疫情防控中,大数据技术发挥了重要作用,个人信息保护再次引起关注。整体而言,日本个人信息保护法以"个人优先"与"公共优先"的宗旨博弈为出发点,以"个人信息"的概念界定为基础,以个人信息权的保护为核心,以个人信息保护机构的独立设置为落脚点,为个人信息的保护奠定了基础。我国应当积极行动起来,尽快颁布《个人信息保护法》,助力大数据时代个人信息保护和数字经济的发展。     

赫哲族伊玛堪代表性传承人生命历程研究——以尤文凤为个案

伊玛堪是赫哲族世代相传的民间说唱艺术形式,2011年被列入联合国教科等“急需保护的非物质文化遗产名录”。运用生命历程理论,结合观察和深度访谈法,选择省级赫哲族伊玛堪代表性传承人尤文凤为个案,考察其学习、传承伊玛堪的具体过程,提出伊玛堪的传承与保护既需要作为个体生命的代表性传承人发挥主观能动性,也需要政府、市场、专家学者、媒体等多种社会力量与其协同合作。     

法医学尸体检验职业防护指南(建议稿)

法医工作者的职业暴露风险极大,案件现场及尸体上的有毒有害物质、高致病性微生物以及利器、骨折等因素均可能给法医带来身心伤害甚至生命危险。随着经济社会发展,法医的工作环境已经较过去显著改善,但是针对个人防护的重视程度仍需提高。近年来公共卫生事件频发,给法医职业防护带来新的挑战,迫切需要借鉴生物安全领域的先进技术和防护理念,以满足新形势下法医工作的需要。本指南立足当前法医职业防护的实际需求,从暴露风险、防护分级、应急处置等角度阐述,希望能为制定法医职业防护相关标准提供参考,以指导法医工作者开展个人防护工作,为提升法医职业化水平和身心健康提供帮助。     

法学研究目标受众选择的大数据分析

文章为谁而写,是法学研究需要解决的基础性命题。从近二十年约2.5万篇法学核心期刊文章的大数据机器学习分类结果看,我国的法学研究成果呈多重目标格局,其中近三成服务于执法机关(包括行政机关和司法机关),同时也有为立法者、执政者建言献策的成果。经检验,目标受众类型的选择与论文的传播能力以及获得基金支持的机会之间有显著相关性。这一决定成果影响力大小的机制迟早会被个体习得并不断强化,成为研究者选择目标受众类型的重要因素。该机制良性运转的关键是处理好学者和实践受众的关系,保持学术研究必要的自主性,警惕学术研究在追逐发表、经济支持时被有关主体“认知俘获”。     

漓江旅游业可持续发展与水生态保护

漓江是桂林的母亲河,是桂林旅游业的精华和精品。要更好地治理漓江,经营漓江,促进漓江旅游业的可持续性发展,必须注重水生态的保护与修复。     

刑事羁押制度-侦查阶段犯罪嫌疑人人权保障分析

我国对犯罪嫌疑人的权利保护与过去相比已经有所改善,但仍存在不少问题,刑讯逼供、超期羁押、违反平等比例原则、侵犯犯罪嫌疑人获得帮助和救济的权利等现象时有发生.文章主要针对上述现象提出一些相应的对策.     

刑事诉讼告知义务初探

告知义务是国家赋予国家机关(含警察、检察官及法官)告知被追诉人(犯罪嫌疑人、被告人)相关的事实、理由及权利的义务,是国家机关在刑事诉讼中承担的关照、帮助被追诉人实现其权利的一项特别义务。设定国家机关的告知义务,有利于保障被追诉人充分行使其权利。不论是国际公约还是一些法治发达国家都有关于告知义务的明确规定。我国刑事诉讼法对于告知义务的规定相对简单,应参照并借鉴国际公约及西方法治发达国家的立法经验,予以修改与完善。     

Fundamental principles of the international protection system of intellectual property rights and the applications

Legal principle, which underlies the value of the legal system, is supposed to be the origin and basis of concrete legal rules. It has also resulted from abstracting and summarizing the value and spirit of these legal rules. In light of the universality and hierarchy of legal principle, the principles of the international protection system of intellectual property rights (IPR) can be divided into the following two types: one is the fundamental principles applied to the what, why and how a legal system shall be constructed, such as principles of sovereignty, equality and mutual benefit, joint development, and international cooperation, which also can be expressed as the principles of sovereignty, international coordination and cooperation, fairness and justice. The other type includes those existing in the legal system and capable of being applied directly, such as the principle of national treatment, principle of minimum standard, principle of independence (for industrial property right), principle of independent protection (for copyright), principle of compulsory implementing patent (for patent right) and doctrine of priority (for industrial property right), etc. In my opinion, the principles of the international protection system of IPR shall follow the latter model, indicating that they shall be provided and written in the international conventions on the grounds that they can be applied directly, and that they can be universally applied to the whole international protection system of IPR instead of exclusive application to one certain system. Hereupon, the author believes that principles concerning the international protection system of IPR should include the principles of national treatment, minimum protection standard and public interest.