Rib Variation at Multiple Locations and Implications for Histological Age Estimation*

Existing histological age estimation methods using the rib were developed mainly from the midshaft; however, in forensic practice, uncertainty of sampling location often arises due to fragmented or previously sampled ribs. The potential for error increases when sampling location is uncertain and utilizing a section beyond the midshaft (either anterior or posterior) may result in erroneous age estimates. Additionally, there is debate within the field regarding the minimum number of sections needed for accurate age estimation. The aim of this research is to determine the importance of the midshaft distinction for age-at-death assessment and the necessity of analyzing serial sections by evaluating histological variables at sampling locations along the length of the rib. Three seriated histological sections at three sampling locations (anterior, midshaft, and posterior) were obtained from sixth ribs of ten postmortem human subjects. Cortical area (Ct.Ar) and osteon population density (OPD) were collected from each section (n = 90). Significant differences were determined in Ct.Ar between sampling locations, demonstrating the variation present along the length of the rib. A comparison of OPD at sampling locations revealed significant differences, suggesting that sampling site is critical to accurate age estimates. When sampling location is uncertain, a more anterior section should be taken. Analysis of serial sections within locations revealed no significant differences in OPD or Ct.Ar, supporting the practice of collecting data from one section for age estimation. While an age estimate can be achieved through the analysis of one section, best practice suggests reading two sections to capture intraindividual variation.     

Swabs as DNA Collection Devices for Sampling Different Biological Materials from Different Substrates

Currently, there is a variety of swabs for collection of biological evidence from crime scenes, but their comparative efficiency is unknown. Here, we report the results of an investigation into the efficiency of different swab types to collect blood, saliva and touch DNA from a range of substrates. The efficiency of extracting blood and saliva from each swab type was also tested. Some swabs were significantly more effective than others for sampling biological materials from different substrates. Swabs with the highest sampling efficiency, however, often did not have the highest extraction efficiency. Observations were recorded regarding practicality of each swab in a variety of situations. Our study demonstrates that selection of sampling device impacts greatly upon successful collection and extraction of DNA. We present guidelines to assist in evaluation of swab choice.     

Identifying the Source of Mystery Waterborne Oil Spills—A Case for Quantitative Chemical Fingerprinting

Oil spills of unknown origin, so-called “mystery” spills, occur routinely in rivers, open water, and navigable coastal waterways. The natural resources damage (NRD) liability associated with even a small volume of oil released into the environment warrants that a thorough chemical characterization of the spilled oil be conducted by agencies and potentially responsible parties (PRPs). Chemical fingerprinting methods have played an important role in the identification of mystery oil spills. These methods fall into two categories, viz., qualitative and quantitative. The qualitative approach relies upon visual comparison of various chromatographic fingerprints obtained by GC/FID and GC/MS analysis of spill and candidate source oils and are represented ASTM methods. The quantitative approach relies upon measurements of the concentrations (relative or absolute) of dozens of diagnostic chemicals, typically PAHs and biomarkers, and a subsequent statistical or numerical analysis of various diagnostic parameters calculated from these concentrations. The quantitative approach is represented by the revised Nordtest methodology. The quantitative approach is preferable for most oil spill investigations since the means of interpretation are objective, whereas the ASTM methods are subjective. Quantitative fingerprinting data are particularly important when the mystery spill and source oils are qualitatively similar and are required when mystery spills may include mixed sources or prespill oil signatures.     

论技术创新生态化的法律制度安排

技术创新生态化有保护生态环境和促进经济发展的双重使命 ,是技术创新的方向。本文在论述技术创新生态化概念的基础上 ,提出并比较详细地论述了保障和促进技术创新生态化的四种法律制度安排即政府推动制度、市场拉动制度、公众参与制度和国际合作制度。     

The natural sampling of airborne trace signals from explosives concealed upon the human body.

An experimental study of the natural sampling of trace signals from explosives concealed upon the human body was performed by taking proper account of the thermal behavior of the air surrounding the human body and the particles therein. Experiments were conducted in a dispersal chamber to identify variables affecting the detectibility of concealed RDX and TNT patches. Movement by human volunteers was found to enhance the available explosive trace signal above a baseline level. Clothing blocked some of this movement-generated trace signal. The detected signal levels were also found to vary significantly from volunteer to volunteer, indicating that human variability is an issue in explosive trace detection. Further, under the conditions studied here, the detectibility of RDX and TNT was dependent upon the efficient sampling of contaminated particulate matter, not the vapor phase. The present results are now being applied to the design of a practical, nonintrusive trace detection portal for aviation security screening and related applications.     

Technology Transfer: A Contextual Approach

A corporation views effective technology transfer as a necessary element for successful operations. Politicians and Government agencies view technology transfer as critical to a competitive domestic economy. This paper compares and contrasts the technology transfer motives and methods of a corporation and a Government research and technology agency to analyze differences. The analysis reveals that the context, or environment, and the motives of the particular organizational level both reflect the method of technology transfer employed. Motives are not necessarily homogenous across organization levels. Therefore, the successful implementation of technology transfer depends upon creating an environment that will capitalize on the motives that exist at each level, and taking an approach that reflects those motives. The Government approach is to broadcast available technology, whereas that of the corporation is to control its release by targeting recipients. For more effective technology transfer, the Government approach should be augmented by a second stage that considers the individual employee's motivation. Therefore, on the basis of the findings, a two-stage approach to successful Government technology transfer is recommended.     

Physician-management relationships at HCA: a case study

The questions of whether Hospital Corporation of America (HCA), a for-profit hospital company, fostered an environment detrimental to the physician-patient relationship during the period of implementation of the Medicare Prospective Payment System (PPS) was explored. The transition to PPS provided an opportunity to evaluate whether hospital ownership differences affected responses to a payment system which encouraged institutional intervention in the practice of medicine. A case study approach was used to observe the influence of the then largest for-profit hospital corporation upon physicians' medical practice in four owned hospitals. Findings indicated that HCA hospital managers were most directly influenced by the local competitive environment and their own personal agendas in responding to PPS incentives. Corporate influence actually softened payment system incentives to intervene in medical practice by providing a generous supply of capital, and by fostering a corporate culture conducive to cooperative relationships with physicians. Better public understanding of the determinants of hospital behavior is needed to preserve or enhance important social goals such as the physician-patient relationship; easily measurable characteristics such as ownership or bed size explain little about hospital behavior or motivation.     

Mathematical theory for a multilateral trade clearing agency

In connection with the article by Professor Ragnar Frisch in this issue of Economics of Planning, we will here present a mathematical formulation of multilateral clearing. The formulation is to a large extent built upon a presentation given by Professor Frisch in Norwegian.¹ But we will also utilize experiences gained from experimentation with some numerical examples.²     

Restoring ordinariness for women offenders: why every wing matters

Abstract

Psychologically informed planned environments (PIPEs) are specifically designed environments where staff members have additional training to increase their psychological understanding of their work. This understanding enables them to create a safe and supportive environment which can help facilitate the development and improvement of those who live there. They aim to maximise ordinary situations in order to support development and to approach this in a psychologically informed way, and by paying particular attention to issues relating to personality disorder. Since PIPEs have been introduced into the Criminal Justice System in 2011, significant improvements in institutional behaviour have been observed. This paper considers the development of the therapeutic environment of a PIPE Unit and in particular its translation for women in custody. Reflecting upon narratives taken from focus groups within a female PIPE Unit in England, it will theorise why, for many women, the environment plays a significant part in their recovery and progression in prison. Although this paper focuses on a PIPE environment, it is suggested that observations can also be transferred to other forensic environments, including therapeutic communities, enabling environments, treatment services, hospital wards, normal wing locations and so forth.     

Intra‐ and Inter‐Element Variability in Mitochondrial and Nuclear DNA from Fresh and Environmentally Exposed Skeletal Remains,

Successful identification of skeletonized remains often relies upon DNA analyses, frequently focusing on the mid‐diaphysis of weight‐bearing long bones. This study explored intra‐bone DNA variability using bovine and porcine femora, along with calcanei and tali. DNA from fresh and short‐term environmentally exposed bone was extracted utilizing demineralization and standard lysis buffer protocols, and DNA quantity and quality were measured. Overall, femoral epiphyses, metaphyses, and the tarsals had more nuclear and mitochondrial DNA than did the femoral diaphyses. DNA loss was much more rapid in buried bones than in surface exposed bones, while DNA quality differed based on environment, but not bone region/element. The demineralization protocol generated more DNA in some bone regions, while the standard lysis was more effective in others, and neither significantly affected DNA quality. Taken together, these findings reinforce the importance of considering inter‐ and intra‐bone heterogeneity when sampling skeletal material for forensic DNA‐based identifications.     

STR遗传多态性调查中样本量和采样方式选择初探

目的对STR基因座进行遗传学调查时样本量大小和采样方式进行考察分析。方法用DNA Typer~(TM)19试剂盒对血卡样本进行直扩,ABI3730型遗传分析仪电泳检测,Genemapper ID v3.2软件进行等位基因分型,根据公式计算群体遗传学参数。计算样本量在50、100、150、200、250、300、350、400、450、500十个水平上遗传多态性水平,并评估与总体的差异。计算常见的四种采样方法(整群采样、随机采样、系统采样、分层采样)所抽取样本遗传多态性水平,并评估抽样误差。结果 18个STR基因座在河北地区16 058份随机样本共检出317种等位基因,基因频率分布在3.114e-5~0.515。18个STR基因座在河北群体水平上PM为6.04e-14,TDP为0.999 999 999 999 94,CEP为0.999 999 987 514 828。PM值、CEP值在样本量大于200后中值基本稳定。四种抽样方法的抽样误差大小是:整群抽样≥单纯随机抽样≥系统抽样≥分层抽样。结论 DNATyper~(TM)19试剂盒的18个STR基因座在河北地区具有较高的遗传多态性水平。在小范围内进行人群频率调查时,可随机选择200份样本代表当地遗传多态性水平。在相对较大范围或遗传背景复杂的区域,可采用分层抽样的方法降低抽样误差。     

Accounting for Variation in Distrust of Local Police

This paper tests a variety of explanations for variation in distrust of local police in the US. As with other attitudes toward the police, there is a substantial race gap in distrust of the police. Our analysis is based upon citizen survey data from 33 cities and data on policing characteristics and the city context for those same cities. It reveals that individual‐level factors representative of a psychological model are of substantial importance in accounting for variation in distrust of the police. City‐level attributes tapping differences in police performance are also important predictors of citizen distrust of the police, even once individual‐level attributes are controlled; and there are important racial differences in the impact of these police performance variables as well, resulting in a largely full accounting of the initial race gap.     

再论环境侵权责任的“原罪”说

一般侵权行为成立的前提是行为的正当性,而特殊侵权行为的特殊性在于特殊行为的潜在风险性。环境侵权行为也具有潜在风险性,但其更本质的特点是改变环境或给环境带来不利影响。这种行为从一开始就注定不可避免地而不是潜在地给环境造成不利影响,这是其"原罪"之所在。让环境侵权行为人承担责任不是基于过错或其他什么理由,而是以环境侵权行为的原罪为根据。     

The role of proximity in university-business cooperation for innovation

The potential for universities to contribute positively to business innovation has received much attention in recent years. While the determinants of university-business cooperation have been examined extensively, less attention has been given to the mediating influence of proximity in this relationship. The analysis in this paper builds on the UK business innovation survey (2002–2005) by incorporating measures of the university research environment for each of the 16,500 businesses surveyed. These measures allow us to look beyond business-level characteristics as determinants of the geography of university cooperation and account for the character of the local university environment. Measures include the distance from each business to its nearest university, the quality of local university research and the density of the university research environment. The findings suggest that significant differences exist between those businesses that cooperate with local universities and those that cooperate with non-local universities. These differences relate to business size, sales profile, location, absorptive capacity and innovation activity. In addition, we also find that if a business is located close to a research excellent university, cooperation tends to remain local, however, the distance between businesses and the nearest university is not a significant determinant of university-business cooperation and further, the higher the concentration of universities in the business locale, the more likely businesses are to cooperate with non-local universities.     

Orogen: Advanced relationship predictions for genetic genealogy

Orogen advances the science of relationship prediction by using Ped-sim, which improves upon previous models by incorporating crossover interference and sex-specific genetic maps. The Orogen tool provides accurate relationship predictions for a wide range of relationship types. It properly differentiates between close relatives at 23andMe, which is a newly available functionality for standalone tools. It provides new granularity of close relationships by showing the differences between paternal and maternal sides and in-group relationship types.     

The rule of law as a catalyst for sustainable democracy in Nigeria

Democracy and the rule of law are the pillars of sustainable development and the guarantee of fundamental freedoms in any society. The rule of law is one of the prerequisites to creating an enabling environment that supports socio‐economic growth and political development. The future of democracy rests with the ability of democratic governments to observe the rule of law. The rule of law is the fulcrum of democracy and the pillar upon which the structures of democracy stands. This article examines the crucial importance of the rule of law as a catalyst for the sustenance of democracy in Nigeria.     

一起自建集中式供水单位生活饮用水不符合卫生标准行政处罚案例评析

卫生行政执法部门在处理群众投诉举报时,对生活饮用水等与健康相关的产品依法进行采样抽检,对样品抽检结果不合格的单位依法对其处罚时,要对相关证据进行核实。通过本案例分析,提示对于检测样品要严格按照相关规范进行采样,对检验结果要依据国家卫生标准进行相关分析,相关程序符合要求,才能依据检验结果适用法律进行行政处罚。     

Sampling and statistical considerations for the Suchey–Brooks method for pubic bone age estimation: Implications for regional comparisons

Although the Suchey–Brooks (SB) system is currently the most widely used method for age-at-death estimation from the pubic bone, the system continues to evolve through stepwise improvements. Since the system was developed from a pubic bone sample derived mainly from North Americans, it is unclear how well it performs on populations from other continents. During the last decade, studies of the SB system on pubic bone samples from local populations in Europe and Asia have indicated regional differences in the relationship between age and pubic bone development. However, these studies have for the most part followed different research protocols, which make comparisons between their results less meaningful. It would be most useful if future regional analysis of the SB system were done in a rigorous and uniform fashion, following standard procedures. In this paper, sampling and statistical considerations are outlined that hopefully will help to standardize research on the SB system.     

Predicting Bureaucratic Control: Evidence from the 1990 Clean Air Act Amendments

The extent to which politicians control bureaucracies that are delegated authority over public policy involves fundamental positive and normative issues for the study of politics. Considerations related to such issues have stimulated a great deal of debate about whether the legislature exercises control over bureaucratic performance. However, establishing the measurable empirical conditions under which elected officials do and do not assure agency responsiveness remains unsettled.
In light of this state of affairs, we try to determine whether it is possible to develop a general means of predicting control, or at least of predicting what we term "intent to control," based on the assumption that legislators' preferences toward agency responsiveness reflect the nature of the policy environment. Our application to the Clean Air Act Amendments of 1990 finds strong empirical evidence that statutory provisions vary predictably, depending upon whether legislators possess the requisite technical ability and are likely, or wish, to be held politically accountable. Our results indicate that control varies for reasons that fit well with our understanding of how elected officials deal with complexity and their own political situations. Our findings also imply that subtle, but measurable, differences in the specific policy environment are crucial for understanding control.     

Computer‐aided Dental Identification: An Objective Method for Assessment of Radiographic Image Similarity*

Abstract: A pilot study evaluated a computer‐based method for comparing digital dental images, utilizing a registration algorithm to correct for variations in projection geometry between images prior to a subtraction analysis. A numerical assessment of similarity was generated for pairs of images. Using well‐controlled laboratory settings, the method was evaluated as to its ability to identify the correct specimen with positive results. A subsequent clinical study examined longitudinal radiographic examinations of selected anatomical areas on 47 patients, analyzing the computer‐based method in making the correct identification based upon a threshold level of similarity. The results showed that at a threshold of 0.855, there were two false negative and two false positive identifications out of 957 analyses. Based on these initial findings, 25 dental records having two sets of full mouth series of radiographs were selected. The radiographs were digitized and grouped into six anatomical regions. The more recent set of films served as postmortem images. Each postmortem image was analyzed against all other images within the region. Images were registered to correct for differences in projection geometry prior to analysis. An area of interest was selected to assess image similarity. Analysis of variance was used to determine that there was a significant difference between images from the same individual and those from different individuals. Results showed that the threshold level of concordance will vary with the anatomical region of the mouth examined. This method may provide the most objective and reliable method for postmortem dental identification using intra‐oral images.