液相色谱-质谱联用同时检测17种常见毒品的定性分析方法

目的 建立同时检测17种常见毒品的液相色谱-质谱联用定性分析方法.方法 对海洛因、吗啡、冰毒、氯胺酮等17种毒品的色谱行为进行了研究,对流动相梯度程序和质谱参数进行了细致考察和优化.采用岛津Shim-pack XR-ODS（100mm×2.0mm,2.2μm）色谱柱,流动相A：0.3％甲酸;流动相B：0.3甲酸乙腈,梯度洗脱程序0min～3min～8min～15min～20min,3％B～18％B～23％B～93％B～93％B,雾化电压5kV,扫描速度3750u/sec,雾化气流量1.5L/min,干燥气流量10L/min.结果 所测17种毒品的21种组分均获得了良好的分离效果和质谱响应,scan模式下检测限（S/N≥3）1.9pg/μL～40.0pg/μL.结论 该方法快速、简便、高效,适合公安办案中对未知毒品进行定性检测.     

GC Analysis of Black Gel Pen Ink Stored under Different Conditions

In many criminal and civil cases in China, the most commonly questioned documents are those written with gel pen ink. An important task for forensic document examiners is to identify whether two or more ink entries in one or more documents were written with the same ink type. The identification of the age of gel ink entries made poses an important and difficult problem for forensic document examiners. In this paper, the volatile components of gel ink were determined and the gel ink was classified by gas chromatography with a flame ionization detector. Calibration curves were created to express the relationship between the content of volatile gel ink components and the age of gel ink entries stored under natural and UV‐induced aging conditions. The correspondence between the natural and UV‐induced aging conditions was also established. The experimental results showed that GC was useful in the analysis of black gel ink and applicable for determining the relative age of gel ink entries under certain conditions.     

以共同育儿为业:跨越儿童抚育的家庭边界——以一个城市社区的“抱团养娃”实践为例

本文聚焦于城市化背景下的"抱团养娃"实践,深入探讨在抚育职责被"家庭化"的当下,抚育实践如何在一定程度上重新跨越"家庭"的边界。以社区共育为基点,妈妈们的努力既从私人层面上为在陌生城市中资源不足的小家庭找到更多社会支持,又在公共层面上带动孩子们以温度和情感重塑社区认同、黏合社会转型带来的制度缝隙,体现出独特的现实意义与支持力量。"以共同育儿为业"背后,是女性试图在既有的结构约束下找到被私人化的抚育照料重担与公共生活之间的连接点,在本研究中体现为共育支持网络的形成、共育友好空间的营造、亲子活动内容的生产和共育文化的建构四个方面。这为思考如何将"社会"重新带回抚育实践中提供了想象,也拓宽了对女性主体性的理解。     

Efficiency over generosity? Evidence of electoral accountability from typhoon dayoff in Taiwan

ABSTRACT

Even though voters may irrationally blame the incumbent for natural disasters, democratic accountability can still hold if voters also reward the government for good responses. This article approaches the response-reward question by exploring the election impact of typhoon dayoff decisions in Taiwan. County mayors are responsible for deciding the dayoffs before a typhoon, so voters can easily and immediately observe the quality of the mayor's decision and fully attribute the outcome to him. Results combining 2005–2014 weather, election, and ten survey datasets show that a correct dayoff, which a dayoff was announced and the storm was tomorrow is harmfully strong, can significantly increase the incumbent's vote share. The effect is larger in the election year. Meanwhile, Taiwanese voters also slightly reward the incumbent for a bonus dayoff, which the storm is unexpectedly weak. Evidence also shows that mayors exploit the incumbent advantage by announcing more correct and bonus dayoffs.     

The Far North Act in Ontario,Canada: a sons of the soil conflict in the making?

In 2010, the Government of Ontario, Canada passed the controversial Far North Act. The Act purportedly aims to promote land use planning and sustainable development while recognising Aboriginal and Treaty rights. There are, however, early warning signs that the Act could be a breeding ground for future conflict between Indigenous peoples and other stakeholder groups. This article adopts a ‘sons of the soil’ conceptual framework to explore the mechanisms that could give rise to the escalation of Indigenous vs. non-Indigenous conflict. The findings provide important insights for theorising the contentious politics around land and territory in diverse settler-colonial contexts.     

固根萃取技术在系统药、毒物分析中的应用

根据反相色谱法及离子交换色谱法的原理,研制了一种固相萃取小柱,建立了筛分系统,可以同时完成对复杂体系中酸性、中性及碱性药、毒物的一次革取净化及富集,适应于系统毒物及药物筛分工作的需要。并对筛分柱的草取机理进行了初步的实验论证。     

Organic impurity profiling of fentanyl samples associated with recent clandestine laboratory methods

Nearly a decade ago, fentanyl reappeared in the United States illicit drug market. In the years since, overdose deaths have continued to rise as well as the amount of fentanyl seized by law enforcement agencies. Research surrounding fentanyl production has been beneficial to regulatory actions and understanding illicit fentanyl production. In 2017, the Drug Enforcement Administration (DEA) began collecting seized fentanyl samples from throughout the United States to track purity, adulteration trends, and synthetic impurity profiles for intelligence purposes. The appearance of a specific organic impurity, phenethyl-4-anilino-N-phenethylpiperidine (phenethyl-4-ANPP) indicates a shift in fentanyl production from the traditional Siegfried and Janssen routes to the Gupta-patent route. Through a collaboration between the DEA and the US Army's Combat Capabilities Development Command Chemical Biological Center (DEVCOM CBC), the synthesis of fentanyl was investigated via six synthetic routes, and the impurity profiles were compared to those of seized samples. The synthetic impurity phenethyl-4-ANPP was reliably observed in the Gupta-patent route published in 2013, and its structure was confirmed through isolation and structure elucidation. Organic impurity profiling results for illicit fentanyl samples seized in late 2021 have indicated yet another change in processing with the appearance of the impurity ethyl-4-anilino-N-phenethylpiperidine (ethyl-4-ANPP). Through altering reagents traditionally used in the Gupta-patent route, the formation of this impurity was determined to occur through a modification of the route as originally described in the Gupta patent.     

Overview of the seized and examined pharmaceutical in the state of Minas Gerais-Brazil by the Civil Police from 2017 to 2022: A fundamental analysis of the recent impact over the drugs market

This work presents a data survey regarding the qualitative chemical analysis of drugs seized by the Police in the state of Minas Gerais between July 2017 and June 2022, including an evaluation of labeling of 265 samples of anabolic androgenic steroids (AAS) seized in 2020. The Active Pharmaceutical Ingredients (API) present in the samples were identified through chemical analysis and classified by system Anatomical Therapeutic Chemical (ATC) methods. Analysis of the labeling information for 265 samples of AAS followed the guidance of legislation RDC 71 (2009) from ANVISA. For this study 6355 seized pharmaceuticals underwent qualitative chemical analysis that corresponded to 7739 APIs successfully identified and classified. Among the components studied AAS, psychostimulants, anesthetics, and analgesics were the most commonly examined. AAS seized and tested increased by over 100% and for the majority of the samples analyzed were found to not match the labeling on the packaging. In the meantime, anti-obesity drugs presented a prominent increase of 400% from 2020/1 to 2021/2, during covid-19 quarantine. Seized pharmaceuticals and tests can support information in the planning of public health and safety policies.     

Evaluating the sensitivity,stability, and cross-reactivity of commercial fentanyl immunoassay test strips

Illicit fentanyl has flooded the United States' drug market, increasing the risk of overdose and poisonings throughout the general population and accidental exposure among law enforcement officers confiscating the increasing number of seizures. Fentanyl test strips (FTS) are used to obtain presumptive information about the presence of fentanyl in a suspected sample. However, their adoption by law enforcement personnel and seized-drug analysts has been limited because most products are advertised for urine testing, not for assays using water solutions. This study presents an evaluation of four commercial FTS: Rapid Response from BTNX, Inc.; T-Dip Fentanyl (FTY) Urine Dip Cards obtained from Amazon.com ; Premier BioDip FYL10 from Premier Biotech Inc.; and MobileDetect Fentanyl strips from DetectaChem, Inc. Performance characteristics curves were used to compare the products' sensitivity, showing that all can reliably detect fentanyl in aqueous solutions at concentrations below 1 μg/mL, with some of the tests able to reliably detect the drug at 200 ng/mL. A stability study demonstrates the performance of all four FTS brands was only slightly affected after 30 days of storage at two extreme environmental conditions. Fentanyl-related substances are also evaluated using the Rapid Response FTS, which showed high cross-reactivity with para-fluorofentanyl and acetylfentanyl, but lower with ortho-chlorofentanyl, carfentanil, and 4-ANPP. Users should be aware that FTS may give false-negative results even when potentially dangerous levels of carfentanil are present. When testing other common drugs, adulterants, and diluents frequently encountered in seized tablets, concentration-dependent results were obtained and multiple instances of false positives were recorded.     

Drugs,law, people,place and the state: ongoing regulation,resistance and change

We introduce this special issue firstly by tracing drugs from their traditional, cultural and religious uses through to their roles as commodities in colonial relations and now the global economy. We secondly explore the shifting nature of drugs and drug use in different places and times as shaped by politics, especially state regulation and the law. Thirdly, given the complexity as well as contingency of drugs, we survey a wide range of relevant theoretical approaches, but suggest that a critical analysis attend to their spatial framing and geography. Fourthly, and finally, we summarize the eight papers comprising this collection.